Comparison of the Effect of Aloe Vera Extract, Breast Milk, Calendit-E, Curcumin, Lanolin, Olive Oil, and Purslane on Healing of Breast Fissure in Lactating Mothers: A Systematic Reviwe

Background: Sore nipples are a common problem in breast-feeding women which can cause early cessation of breast-feeding. We aimed to evaluate the effect of Aloe Vera extract, breast milk, Calendit-E, Curcumin, Lanolin, Olive oil, and Purslane on healing of breast fissure in lactating mothers. Materials and Methods: All clinical trials evaluating the effect of Aloe Vera extract, breast milk, Calendit-E, Curcumin, Lanolin, Olive oil, and Purslane on healing of breast fissure in lactating mothers were searched on the online databases of Scopus, EMBASE, Cochrane, Web of Science and Medline with no language or time restrictions using the combination related keywords of Mesh. Study selection was done by two reviews. Results: Six studies were included here with a total sample size of 546 subjects. The results showed that aloe vera gel and Purslane cream are more effective than lanolin ointment for healing sore nipples. Calendit-E cream, and aloe vera gel were more effective than breast-fed milk for treating sore nipples. However, no significant difference was observed between the mother's breast milk group and olive oil. Concerning the limited side effects, as well as greater impact and antimicrobial activity of curcumin in the short term, it was suggested to use curcumin for treating sore nipples. Conclusion: Aloe vera gel and purslane cream, Calendit-E cream, and curcumin can have beneficial effects on improving sore nipples. Usage of these therapeutic methods is suggested to improve sore nipples given their low cost and limited side effects.