Author/Authors :
Karami, Hassan Pediatric Infectious Diseases Research Center - Faculty of Medicine - Mazandaran University of Medical Sciences, Sari, Iran , Kianifar, Hamid-Reza Allergy Research Center - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Khakshour, Ali Department of Pediatrics - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Vakili, Rahim Department of Pediatric Endocrinology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Khalighi, Negar Allergy Research Center - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Jafari, Seyedali Department of Pediatric Gastroenterology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Hiradfar, Simin Anatomical Pathologist - Reference Laboratory - Treatment Administration - Mashhad University of Medical Sciences, Mashhad, Iran , Heidari, Elahe Department of Pediatrics - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Background: Cystic fibrosis (CF) is a multi-systemic disorder with an autosomal recessive inheritance. It is characterized by recurrent
pulmonary infections and gastrointestinal problems, particularly pancreas insufficiency.
Objectives: The aim of this study was to evaluate growth peptides in CF patients.
Methods: This cross sectional study was approved by Mashhad University of Medical Sciences ethical committee. Patients were
between six months to 18 years old, who were referred to Dr. Sheikh Hospital subspecialty clinic. They were enrolled for the study
after obtaining a written constant. Demographic data was recorded. Of all cases, 10-cc blood sample was obtained and growth
peptide levels were determined and measured. Data were analyzed by SPSS version 16 and Mann Whitney and 2 tests were used.
Results: Patients’ mean age at onset was 3.4 1.1 months. Overall, 36 (60%) children were male and 24 (40%) were female. Mean
body mass index (BMI) was 15.9 3.2 kg/m2. Mean levels of growth hormone was 1.9 0.37 (ng/mL), insulin-like growth factor 1
(IGF1) was 85.89.6 microg/L and insulin-like growth factor binding protein 3 (IGFBP3) level was 1853810643 pg/mL.
Conclusions: The mean serum levels of GH, IGF1, and IGFBP3 in CF children with growth failure was lower than children without
growth failure. Regarding the relatively high prevalence of growth disorders in children with cystic fibrosis, selected, appropriate,
and standard medical treatments could improve the outcome for these children.
