Author/Authors :
Waheed Janabi, Alhamzah Hasan State Key Laboratory of Natural Medicines - School of Pharmacy - China Pharmaceutical University - Nanjing 211198 - Jiangsu Province - PR China , Kamboh, Asghar Ali Department of Veterinary Microbiology - Faculty of Animal Husbandry and Veterinary Sciences - Sindh Agriculture University Tandojam 70060, Pakistan , Saeed, Muhammad Faculty of Animal Production and Technology - Cholistan University of Veterinary and Animal Sciences - Bahawalpur 6300, Pakistan , Xiaoyu, Lu State Key Laboratory of Natural Medicines - School of Pharmacy - China Pharmaceutical University - Nanjing 211198 - Jiangsu Province - PR China , BiBi, Jannat Department of Physical Education - Shaanxi Normal University - Xian - Shaanxi Province, P.R China , Majeed, Fatima School of Public Health - Nanjing Medical University - Jiangsu Province - 211166, P.R China , Naveed, Muhammad School of Pharmacy - Nanjing Medical University - Jiangsu Province - 211166, P.R China , Jameel Mughal, Muhammad Faculty of Health Sciences - University of Macau - Avenida de UniversidadeTaipa, Macau , Korejo, Nazar Ali Department of Veterinary Medicine - Faculty of Animal Husbandry and Veterinary Science - Sindh Agriculture University - Tandojam 70060, Pakistan , Kamboh, Rubina Liaquat University of Medical and Health Sciences - Jamshoro, Pakistan , Alagawany, Mahmoud Departmentof Poultry - Faculty of Agriculture - Zagazig University - Zagazig 44511, Egypt , Lv, Huixia State Key Laboratory of Natural Medicines - School of Pharmacy - China Pharmaceutical University - Nanjing 211198 - Jiangsu Province - PR China
Abstract :
It is well documented that life expectancy in developed countries at birth is going to surpass the
20th century. However, regrettably, a potential decline in life expectancy has been proposed for these
nations in the 21st century due to a rapid upsurge in the prevalence of fatal degenerative diseases
like cardiovascular diseases (CVD), cancer and diabetes. Collectively, these three diseases accounted
for 65% of all deaths in urbanized societies and were considered as a dynamic issue for shortening
the genetically determined lifespan through increased mortalities, morbidities, disabilities, immense
sufferings, and premature aging. These fatal degenerative diseases and premature aging are closely
associated with oxidative stress produced by the free radicals in the body. In epidemiologic studies,
flavonoid-rich foods (FRF) like fruits, vegetables, and beverages have been associated as protective
agents against these diseases. These also have been observed for their geroprotective effects and help in
preventing premature aging and deterioration of brain function, which is related to Alzheimer’s disease
and dementia. In this review, we presented a comprehensive overview of the FRF for their potential role
against lifespan-shortening complications, i.e., CVD, cancer, and diabetes. We also have drawn the future
perspective and dietary guidelines to reduce the fatal disease burden in urban populations.
Keywords :
Anti-oxidants , Cancers geroprotective , Cardiovascular diseases , Diabetes , Dietary supplements , Nutraceuticals
