Author/Authors :
Jamre, Mina Faculty of Energy Engineering and Physics - Amirkabir University of Technology, Tehran, Iran , Shamsaei, Mojtaba Faculty of Energy Engineering and Physics - Amirkabir University of Technology, Tehran, Iran , Ghannadi Maragheh, Mohammad Radiation Application Research School - Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran , Sadjadi, Sodeh Material and Nuclear Fuel Cycle School - Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
Abstract :
Novel biodegradable Poly (L-lactic acid) (PLLA) microspheres containing ytterbium were
designed for intra-tumoral radiotherapy, especially for radioembolization. 175Yb possess both
therapeutic beta and diagnostic gamma radiations. In this work, a process of making ready
radiomicrospheres 175Yb (acac)3-loaded PLLA for more consideration has been investigated.
The radiomicrospheres were prepared with approximate size of 20-40 μm, and radionuclidic
purity > 92%. The radiomicrospheres were stable in-vitro for up to 72 h in normal saline,
and also in human serum albumin (HSA). Biodistribution in mice bearing 4T1 tumor showed
specific radionuclide uptake over 48 h. Tumor necrosis was also observed at the injection site
up to 12 days after injection. These data indicated that 175Yb-PLLA microspheres could be
prepared and considered further for radiomicrospheres tumor therapy.
Keywords :
Poly (L-lactic acid) , Radio microsphere , Ytterbium-175 , Tumor therapy , Reactor
