Author/Authors :
Mozayeni, Farnaz Allergy Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Rezaee, Abdolrahim Immunology Research Center - Inflammation and Inflammatory Disease Division - Mashhad University of Medical Sciences , Jabbari Azad, Farahzad Allergy Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Shabestari, Mahmoud Department of Cardiology - Emam Reza Hospital - School of Medicine - Mashhad University of Medical Sciences , Faridhosseini, Reza Allergy Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Rafatpanah, Houshang Immunology Research Center - Inflammation and Inflammatory Disease Division - Mashhad University of Medical Sciences , Yousefzadeh, Hadis Immunology Research Center - Bu Ali Research Institute - Student Research Committee - School of Medicine - Mashhad University of Medical Sciences , Garivani, Yousef Ali Department of Cardiology - Emam Reza Hospital - School of Medicine - Mashhad University of Medical Sciences , Jarahi, Lida Addiction Research Center - Mashhad University of Medical Sciences - Faculty of Medicine , Valizadeh, Narges Immunology Research Center - Inflammation and Inflammatory Disease Division - Mashhad University of Medical Sciences , Sabet, Faezah Immunology Research Center - Inflammation and Inflammatory Disease Division - Mashhad University of Medical Sciences , Moshirahmadi, Sharare Department of Cardiology - Emam Reza Hospital - School of Medicine - Mashhad University of Medical Sciences , Mohammadi, Fatemeh Sadat Allergy Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Shabestari, Mohammad Department of Cardiology - Emam Reza Hospital - School of Medicine - Mashhad University of Medical Sciences
Abstract :
Objective(s): Coronary artery disease (CAD) is known as a life threatening disease, worldwide. In
this study the role of HTLV-1 infection was evaluated on cardiac involvement in an endemic region of
northeastern Iran.
Materials and Methods: Serologic and molecular tests for HTLV-1 infection were carried out in subjects
who had coronary angiography. A real-time PCR, TaqMan method, to quantify HTLV-1 proviral load (PVL),
and routine hematological and biochemical tests were performed for study subjects.
Results: Twenty nine patients were HTLV-1+CAD+ and 13 cases were HTLV-1+CAD-. Although, there
were no significant differences for risk factors like FBS, HDL, triglyceride, systolic and diastolic blood
pressure (Cbp, Dbp), waist circumference (WC), hip circumference (WL), cholesterol (P=0.003), and
LDL (P=0.007) levels, and monocyte count (P=0.05) had meaningful differences. The mean HTLV-1
PVL in HTLV-1+CAD+ subjects was 992.62±120 which was higher compared with HTLV-1+CAD- group
(406.54±302 copies/104 PBMCs). Moreover, HTLV-1 PVL in males (833±108) was lower compared
with females (1218±141 copies/104 PBMCs) (P=0.05). Patients with HTLV-1-PVL of more than 500
copies/104 had more diffused atherosclerosis plaque than patients with less than 500 (OR=6.87,
95% CI=1.34-35.05; P=0.016). Furthermore, patients with diffused coronary atherosclerosis had
significantly higher levels of HTLV-1 PVL than patients with middle, proximal, and normal location of
coronary sclerotic lesions (P<0.05).
Conclusion: Taken together, in endemic area, HTLV-1 infection, more likely is a facilitating factor for
heart complications and the high HTLV-1 PVL might affect CAD manifestations.
Keywords :
Cardiac involvement , Coronary artery disease , HTLV-1 , HTLV-1 Proviral load , Real-time PCR
