Author/Authors :
Selener, Mariana G Cátedra de Farmacognosia - Facultad de Farmacia y Bioquímica - Universidad de Buenos Aires, Buenos Aires, Argentina , Elso, Orlando Cátedra de Farmacognosia - Facultad de Farmacia y Bioquímica - Universidad de Buenos Aires, Buenos Aires, Argentina , Grosso, Carla Cátedra de Farmacognosia - Facultad de Farmacia y Bioquímica - Universidad de Buenos Aires, Buenos Aires, Argentina , Borgo, Jimena Cátedra de Farmacognosia - Facultad de Farmacia y Bioquímica - Universidad de Buenos Aires, Buenos Aires, Argentina , Clavin, Maria Cátedra de Farmacognosia - Facultad de Farmacia y Bioquímica - Universidad de Buenos Aires, Buenos Aires, Argentina , Malchiodi, Emilio L Instituto de Microbiología y Parasitología Médica (IMPaM) (UBA-CONICET) - Facultad de Medicina, Buenos Aires, Argentina , Cazorla, Silvia I Centro de Referencia para Lactobacilos (CERELA) (CONICET), San Miguel de Tucumán, Argentina , Redko, Flavia Cátedra de Farmacognosia - Facultad de Farmacia y Bioquímica - Universidad de Buenos Aires, Buenos Aires, Argentina , Sülsen, Valeria P Cátedra de Farmacognosia - Facultad de Farmacia y Bioquímica - Universidad de Buenos Aires, Buenos Aires, Argentina
Abstract :
The anti-Trypanosoma cruzi activity of extracts from 13 Argentinean Asteraceae species
was determined. Dichloromethane and methanol extracts of Acmella bellidioides, Aspilia
silphioides, Viguiera tuberosa, Calyptocarpus biaristatus, Hyalis argentea, Helenium
radiatum, Gaillardia megapotamica, Verbesina subcordata, Gymnocoronis spilanthoides,
Viguiera anchusaefolia, Thelesperma megapotamicum, Zexmenia buphtalmiflora, and
Vernonia plantaginoides were evaluated in-vitro against Trypanosoma cruzi epimastigotes. A.
silphioides, V. tuberosa, V. subcordata, G. spilanthoides, G. megapotamica, T. megapotamicum
and Z. buphtalmiflora dichloromethane extracts showed trypanocidal activity with inhibitions
higher than 60% at a concentration of 10 μg/mL. The methanol extracts of H. radiatum and G.
megapotamica were the most active with inhibitions of 70.1 and 77.7%, respectively at 10 μg/
mL. The chromatographic profiles of the most active extracts showed bands and major peaks
that could be attributed to flavonoids and terpenoid compounds.
Keywords :
Trypanosoma cruzi , terpenoids , Flavonoids , Chagas' disease , Asteraceae
