Title of article :
Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
Author/Authors :
Jafarinia, Mojtaba Department of Genetic - Marvdasht branch - Islamic Azad University - Marvdasht , Hadinia, Abolghasem Department of Genetic - Marvdasht branch - Islamic Azad University - Marvdasht , Goodarzi, Hamed Reza Department of Genetic - Marvdasht branch - Islamic Azad University - Marvdasht , Doustimotlagh, Amir Hossein Cellular and Molecular Research Center - Yasuj University of Medical Sciences - Yasuj, Iran , Arya, Arash Internal Medicine - Yasuj University of Medical Sciences - Yasuj, Iran
Abstract :
Pro-inflammatory cytokines are associated with systemic inflammatory
responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1,
IL-6, and TNF-) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic
steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control
study was conducted on 30 patients with NAFL, 30 patients with NASH, and 30 healthy
volunteers. The plasma level of IL-1, IL-6, and TNF- were determined by ELISA,
and biochemical parameters were measured using colorimetric methods. Results: IL-1
and IL-6 levels were significantly higher in patients with NASH compared with NAFL
and control group. However, TNF- levels had no significant variations in NAFL and
NASH patients compared to the control group (p=0.903 and p=0.960, respectively).
Conclusion: Results showed that the levels of ALT activity and pro-inflammatory
cytokines were higher in patients with NASH compared to control and NAFL subjects;
Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory
factors in NASH.
Keywords :
Tumor Necrosis Factor-α , Non-Alcoholic Steatohepatitis , Non-Alcoholic Fatty Liver , Interleukin-1β, Interleukin-6
Journal title :
Astroparticle Physics
