Title of article
Pathophysiology of Ischemia/Reperfusion-induced Myocardial Injury: What We Have Learned From Preconditioning and Postconditioning?
Author/Authors
BALAKUMAR, PITCHAI ISF College of Pharmacy , PATELIYA, BHARAT Punjabi University - Department of Pharmaceutical Science and Drug Research , SINGH, GURFATEH ISF College of Pharmacy , SINGH, MANJEET ISF College of Pharmacy
Pages
8
From page
115
To page
122
Abstract
Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechanisms involved in the pathophysiology of ischemia/reperfusion injury. Moreover, the pharmacology of preconditioning and postconditioning is delineated.
Keywords
Ischemia/reperfusion injury , Preconditioning , Postconditioning
Journal title
Astroparticle Physics
Serial Year
2008
Record number
2487877
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