Author/Authors :
Shojaeifard, Maryam Echocardiography Research Center - Rajaie Cardiovascular, Medical, and Research Center - Iran University of Medical Sciences, Tehran, IR Iran , Omidi, Negar Cardiac Primary Prevention Research Center - Department of Cardiology - School of Medical Sciences, Tehran, IR Iran , Homatash, Saba Rajaie Cardiovascular, Medical, and Research Center - Iran University of Medical Sciences, Tehran, IR Iran , Daryanavard, Ali Rajaie Cardiovascular, Medical, and Research Center - Iran University of Medical Sciences, Tehran, IR Iran , Esmaeli, Anahita Rajaie Cardiovascular, Medical, and Research Center - Iran University of Medical Sciences, Tehran, IR Iran , Rahmanpour, Hamidreza Rajaie Cardiovascular, Medical, and Research Center - Iran University of Medical Sciences, Tehran, IR Iran , Erami, Sajad Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran , Dehghani Mohammad Abadi, Hossein Shahid Sadoughi Hospital - Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran
Abstract :
Background: There are insufficient data on the association between the serum level of vitamin D and
the carotid intima-media thickness (CIMT). The aim of this study was to investigate the association
between the level of serum 25-hydroxyvitamin D and the CIMT.
Methods: This cross-sectional study recruited 341 patients. The level of 25-hydroxyvitamin D was
measured with radioimmunoassay, and the CIMT was measured with color Doppler ultrasound.
Results: The mean serum level of 25-hydroxyvitamin D was 14.88±14.63 ng/mL in the patients
with a significant carotid artery involvement and 17.02±13.56 ng/mL in those without a
carotid involvement, with the difference between the 2 groups constituting statistical
significance (P=0.034). The prevalence rate of vitamin D deficiency in those with and without
a carotid involvement was 88.6% and 74.4%; the rate was significantly higher in the former
group (P=0.039).
Conclusions: Our study confirmed recent suggestions regarding the association between vitamin D
deficiency and the progress of atherosclerosis in carotid arteries as CIMT.
Keywords :
Atherosclerosis , Intima-media thickness , Carotid plaque , Vitamin D deficiency
