Author/Authors :
Dideban, Ali Human Genetics Research Center - Baqiyatallah University of Medical Sciences, Tehran , Seyedrezazadeh, Ensiyeh Tuberculosis and Lung Disease Research Center - Tabriz University of Medical Sciences, Tabriz , Sharifi, Akbar Tuberculosis and Lung Disease Research Center - Tabriz University of Medical Sciences, Tabriz , Abd-Nikfarjam, Bahareh Department of Immunology - School of Medicine - Qazvin University of Medical Sciences , Sadeghi, Morteza Human Genetics Research Center - Baqiyatallah University of Medical Sciences, Tehran
Abstract :
Background: Lung cancer is the first cause of cancer deaths worldwide.
Polymorphisms in microRNAs genes affect their structure and their attachment
to target genes. The purpose of the present study was to investigate the association
of miR-146a rs2910164 polymorphism with the risk of non-small cell lung cancer
(NSCLC) in Iranian patients.
Methods: This case-control study was performed among 103 patients with
lung cancer and 100 healthy controls. The genotyping of miR-146a rs2910164
polymorphism was assayed by polymerase chain reaction–restriction fragment
length polymorphism (PCR–RFLP) and a number of samples were sequenced
for final approval.
Results: A significant association was found between rs2910164 polymorphism
CG genotype and risk of lung cancer progression in dominant models (CG vs.
GG: OR=1.855, CI=1.09-3.33, P=0.03). There was no association between the C
allele and frequency of rs2910164C>G polymorphism and risk of lung cancer
(C vs. G: OR=1.54, CI=0.97-2.44, P=0.08).
Conclusion: There was a significant association between miR-146a rs2910164
polymorphism and lung cancer in Iranian population. This polymorphism can
be considered as a risk factor of non-small cell lung cancer.
Keywords :
MicroRNA-146a , Polymorphism , Lung cancer , Risk factor
