Title of article :
The Role of Dietary Antioxidants on Oxidative Stress in Diabetic Nephropathy
Author/Authors :
Preciado-Figueroa, Francisco Martín Nephrology Service - Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara - Jalisco, Mexico , Yanowsky-Escatell, Francisco Gerardo Nephrology Service - Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara - Jalisco, Mexico , Andrade-Sierra, Jorge Nephrology Service - Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara - Jalisco, Mexico , Pazarín-Villaseñor, Leonardo Nephrology Service - Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara - Jalisco, Mexico , Santana-Arciniega, Christian Surgery and Clinical Nutrition Service - Civil Hospital of Guadalajara Dr. Juan I. Menchaca - Guadalajara - Jalisco, Mexico , Torres-Vázquez, Eduardo de Jesús University Health Sciences Center (Centro Universitario de Ciencias de la Salud) - University of Guadalajara - Guadalajara 0 Jalisco, Mexico
Abstract :
Diabetic nephropathy (DN) is the leading cause of end-stage renal
disease and oxidative stress (OS) has been recognized as a key
factor in the pathogenesis and progression. Hyperglycemia, reactive
oxygen species, advanced glycation end products, arterial pressure,
insulin resistance, decrease in nitric oxide, inflammatory markers,
and cytokines, among others; are involved in the presence of OS
on DN. This revision focus on diverse studies in experimental and
human models with diabetes and DN that has been demonstrated
beneficial effects of different dietary antioxidant as resveratrol,
curcumin, selenium, soy, catechins, α-lipoic acid, coenzyme Q10,
omega-3 fatty acids, zinc, vitamins E and C, on OS and the capacity
for antioxidant response. Therefore, this interventions could have
a positive clinical impact on DN.
Keywords :
dietary antioxidants , diabetic nephropathy , oxidative stress
Journal title :
Astroparticle Physics
