Determination of antibiotic sensitivity by E-test in resistant Enterococcus species isolated from patients admitted in Khatam- Ol - Anbiya, Hospital, Tehran, Iran, 2013-15

Enterococcus is the second cause of urinary tract infections in hospitals and the third most common cause of nosocomial bacteremia. Overuse of antibiotics for the treatment of nosocomial infections, causes antibiotic resistance in enterococci resistant to antibiotics through their ability to acquire resistance to antibiotics through mutation or acquisition of genetic material carrying a resistance gene by conjugation or other methods. This cross-sectional project, 60 patients with nosocomial infections admitted to the Khatam – Ol- Anbiya Hospital wards during 2013-2015 were studied. Samples were collected and sent to the microbiology laboratory. Drug-resistant of Enterococcus and Antibiogram test performed by ETest method. Relevant descriptive variables were analyzed by SPSS software version 21. 34 (56/7%) of patients were male. The patient's mean age was 70.71± 18.39 years. Age group of 70-90 years, with 17 (27.9 %) which was the most frequent nosocomial infections. Enterococcus dominant species in these patients was 45 (75%) Enterococcus faecalis. Antibiogram E-Test results showed that 9 cases (18.3%) were resistance to linezolid, 22 (36/7 %) resistance to imipenem, 15 (25 %) resistance to meropenem, 6 patients (10% ) resistance to teicoplanin, 9 (15%) were resistant to vancomycin Identification of common antibiotic resistance in every region has great importance and in addition prevents treatment failure. The result of these studies shows that antibiotic-resistance patterns have changed and vancomycin resistance especially among E. faecium, is rising because of nosocomial infections.