Author/Authors :
Kezetas Bankeu, Jean Jules Department of Chemistry - Faculty of Science - The University of Bamenda, Bambili , Dawé, Amadou Department of Chemistry - Higher Teacher Training College - University of Maroua, Maroua , Mbiantcha, Marius Department of Animal Biology - Faculty of Science - University of Dschang, Dschang , Tchouya Feuya, Guy Raymond Department of Chemistry - Faculty of Science - Scientific and Technical University of Masuku, Franceville , Ali, Iftikhar Department of Chemistry - Karakoram International University, Gilgit-Baltistan , Tchuente Tchuenmogne, Marthe Aimée Department of Chemistry - Faculty of Science - University of Yaoundé I, Yaoundé, , Mehreen, Lateef Pharmaceutical Research Centre of Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi , Ndjakou Lenta, Bruno Department of Chemistry - Higher Teacher Training College - University of Yaoundé I, Yaoundé , Shaiq Ali, Muhammad International Center for Chemical and Biological Sciences - University of Karachi, Karachi , Silvère Ngouela, Augustin Department of Chemistry - Faculty of Science - University of Yaoundé I, Yaoundé,
Abstract :
Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein, we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae Delile resulting in the isolation of a new ceramide named nkwenamide (1). In addition, seven known compounds including the binary mixture of β-amyrin palmitate (2) and lupeol palmitate (3), olean12-en-3-one (4), n-hexacosan-1-ol (5), β-sitosterol (6), and mixture of β-amyrin (7) and lupeol (8) were isolated. Their structures were elucidated using spectroscopic methods. The methanol extract from the figs of this plant exhibited urease, and α-glucosidase inhibitory activities and showed DPPH radical scavenging potency with IC50 values, 61.7, 73.7 and 87.4 µg/mL, respectively. It also showed a weak chemiluminescence activity as compared to ibuprofen. The mixture of 2 and 3 exhibited maximum urease inhibitory activity with IC50=23.9 µg/mL while the mixture of 7 and 8 showed the maximum α-glucosidase inhibition with an IC50 value of 44.0 µg/mL. All the isolates showed weak chemiluminescence activity.
Keywords :
Ficus vallis-choudae , Isolation , Nkwenamide , Bioactive compounds , Antioxidant activity , Biological activity
