Author/Authors :
Mahboubi, Mohaddese Microbiology Department - Medicinal Plant Research Center of Barij, Kashan, Iran , Feizabadi, Mohammad Mehdi Department of Microbiology - School of Medicine - Tehran University of Medical Science, Tehran, Iran , Khamechian, Tahereh Department of Pathology - Faculty of Medicine - Kashan University of Medical Sciences, Kashan, Iran , Kazempour, Nastaran Microbiology Department - Medicinal Plant Research Center of Barij, Kashan, Iran , Razavi Zadeh, Mohsen Department of Gastroenterology - Beheshti Hospital - Kashan University of Medical Sciences, Kashan, Iran , Sasani, Farhang Department of Pathology - Faculty of Veterinary Medicine - Tehran University, Tehran, Iran , Bekhradi, Mohsen Formulation Department - Medicinal Plant Research Center of Barij, Kashan, Iran
Abstract :
BACKGROUND Staphylococcus aureus is one of the most causative organisms in the skin wound infections. Development of resistant S. aureus to current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection. METHODS The efficacy of herbal formulation containing Oliveria decumbens and Pelargonium graveolens essential oils was evaluated in comparison to mupirocin against Methicillin Resistant S. aureus (MRSA) related skin wound infection in mice animal model. RESULTS The herbal cream and mupirocin decreased the log CFU by 2.5±0.26 and 2.46±0.32, respectively, while the log CFU of S. aureus from wound skin were 5.9±0.26 and 5.65±0.23 for placebo and control groups, respectively. Moreover, the histological examinations showed that this cream improved the wound healing and increased the collagen deposition and wound contraction. CONCLUSION This natural new formulation with O. decumbens and P. graveolens essential oils could be recommended as a new candidate for wound healing.
Keywords :
Oliveria decumbens , Pelargonium graveolens , Healing , Infected wound , Mouse
