Title of article :
Solvent-free Biginelli Reaction Catalyzed to Synthesis of Biologically Active 3,4-dihydropyrimidin-2-(1H) –ones/thiones Derivatives
Author/Authors :
Mohamadpour, Farzaneh Young Researchers and Elite Club - Shiraz Branch, Islamic Azad University, Shiraz
Abstract :
A convenient and highly efficient procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)- one/thione derivatives via one-pot three-component Biginelli condensation of aryl aldehydes,urea/thiourea and ethyl/methyl acetoacetate in the presence of Zn(SO4)2.7H2Oas an efficient, readily and inexpensive catalyst under solvent-free conditions have been studied. This protocol has advantages such as readily available and non-toxic catalyst, short reaction times, good to high yields, solvent-free conditions, facile reaction profiles, high atom-economy and simple work-up.
Keywords :
Zn(SO4)2.7H2O , 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives , low-cost and nontoxic catalyst , Solvent-free conditions
