Title of article
Cold Agglutinin Disease in Non-Secretory Multiple Myeloma: A Case Report
Author/Authors
Abbaszadeh ، Mahsa Department of Internal Medicine - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences , Radkhah ، Hanieh Department of Internal Medicine - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences , Karimpour reyhan ، Sahar Department of Internal Medicine - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences , Khajavirad ، Nasim Department of Internal Medicine - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences
Pages
5
From page
110
To page
114
Abstract
Skin involvement is not common as the first manifestation of Multiple Myeloma (MM). Although extremely rare, leucocytoclastic vasculitis, plasmasytoma, autoimmune bullous disease, livedo reticularis and Raynaud’s phenomenon may be the initial presentation of MM. Raynaud’s phenomenon and livedo reticularis related to cold exposure can be due to Cold Agglutinin Disease (CAD) or cryoglobulinemia and can be seen as the first manifestation of MM. In this case study, we described a 55-year-old man complaining of limbs livedo reticularis and Raynaud’s phenomenon during cold weather. Further evaluations revealed anemia and elevated ESR. Skull X-ray showed multiple punched-out lesions. Finally, serum protein electrophoresis and bone marrow aspiration confirmed the diagnosis of non-secretory MM as the underlying disease of CAD. The patient was referred to the hematologist for the treatment of MM.
Keywords
Cold agglutinin , Multiple myeloma , Raynaud’s phenomenon , Anemia
Journal title
Case Reports in Clinical Practice
Record number
2495379
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