Author/Authors :
Piltan, Mohammad Department of Chemistry - Faculty of Science - Sanandaj Branch, Islamic Azad University, Sanandaj , Zarei, Amir Department of Chemistry - Faculty of Science - Sanandaj Branch, Islamic Azad University, Sanandaj , Saydi, Hassan Department of Chemistry - Faculty of Science - Sanandaj Branch, Islamic Azad University, Sanandaj , Shahvelayati, Ashraf Department of Chemistry - Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran
Abstract :
An efficient approach to the synthesis of 1,2,3-trisubstituted indolizines is described via one-pot reactions of pyridine and dialkyl acetylendicarboxylate in the presence of ethyl 2-chloroacetoacetate in MeOH at room temperature. The corresponding 1, 2, 3-trisubstituted indolizines may be useful building blocks for the construction of complex indolizine derivatives.
Keywords :
Indolizines , Dialkyl acetylendicarboxylate , Pyridines , Ethyl 2-chloroacetoacetate
