Molecular Clock and Autoimmune Diseases; An Approach to Rheumatoid Arthritis; A Review

Circadian clock refers to a biological cycle that fluctuates in a period of ~24 hours. These cycles are supported by a molecular clock and provide a temporal timerelated matrix that ensures the collocation of homeostasis processes with the course of environmental changes. Here in this mini-review, we are going to summarize all recent finding from the last five years till date in the field of circadian and evolutionary clock research in approach to rheumatoid arthritis as the world’s most prevalence autoimmune disease with rate of over 76 million in world population and prevalence of near 0.6% of US which is almost 1.29 million people in the year 2015. Rheumatoid arthritis shows a verity of symptoms besides morning stiffness and increased joint pain in the early morning. This morning joint and stiffness aca correlate to an elevated level of pro-inflammatory cytokines include interleukin-6. The circadian clock has a regulatory role in activity and expression of proteins and their gene which comes under cycle which takes part in autoimmune disease expression and progression, such as fat-derived adipokines and few nuclear receptors. Based on current knowledge which expanding each and every moment we know the pathways that how inflammatory responses regulated base on that working in a new age in the treatment of autoimmune disease especially rheumatoid arthritis.