Title of article :
Trichloroacetic Acid as an Efficient Catalyst for One-pot Synthesis of Highly Functionalized Piperidines via multi-component Reaction
Author/Authors :
Hazeri, Nourallah Department of Chemistry - Faculty of Science - University of Sistan & Baluchestan, Zahedan , Fereidooni, Elham Department of Chemistry - Faculty of Science - University of Sistan & Baluchestan, Zahedan
Abstract :
Trichloroacetic Acid (TCA) was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes and β-keto esters in MeOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and an easy work-up.
Keywords :
Piperidines , Trichloroacetic Acid , Multi-component reaction , β-keto esters
