Title of article :
Synthesis and Screening of Some New Isatin Containing Thiazole Derivatives for Antimicrobial Activity
Author/Authors :
Adhikari, Suman Department of Pharmaceutical Chemistry - Netaji Subhas Institute of Pharmacy, Roypara, India , Bari, S. B. Department of Pharmaceutical Chemistry - R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India , Samanta, A. Department of Pharmaceutical Chemistry - Netaji Subhas Institute of Pharmacy, Roypar, India
Abstract :
In the present work, a series of new N’-[{5-(4-aryl) 1,3-thiazol-2yl}carbohydrazide-methyl]- 3(4-arylimino) indol-2-one analogs (5a-g) had heen synthesized from 3-(4-arylimino)-2-oxo- 1-indole-acetylthiosemicarbazide (4a-g) in ethanol, in the presence of phenacyl bromide or substituted phenacyl bromides. The compound 5e was characterized by its elemental analysis, IR, 1 HNMR and Mass Spectroscopy. The synthesized compounds (5a-g) were evaluated for in vitro antibacterial activity and antifungal activity against various strains of bacteria and fungi.
Keywords :
isatin , 1,3 Thiazole , Antibacterial , Antifungal
