The role of ferulic acid in the amelioration of kidney changes of rats exposed to electromagnetic radiation

Background: Electromagnetic radiation (EMR) is responsible for many hazardous impacts on living organisms. We aimed to investigate the effects of EMR on kidney tissue in rats in order to predict possible effects on human kidneys and to study the radioprotective effect of ferulic acid (FA). Materials and Methods: Six rats were used as controls, six rats were used as treated group with FA, six rats were used as irradiated group and six rats were given both FA and exposed to EMR. Blood samples were taken from the heart forIL6, IL10 and TNF-α analysis in the sera, and a part of rat kidneys was homogenized for analysis of total antioxidant capacity (TAC) and lactate dehydrogenase (LDH).Another part of kidney tissue was used for histopathological studies. Results: Irradiated rats showed a significant increase in the level of renal markers (urea and creatinine) and inflammatory markers (IL6, IL10 and TNFα) However, these effects were ameliorated in the group which was exposed to EMR and treated with ferulic acid (FA + EMR). TAC and LDH measured in kidney tissues were significantly decreased in irradiated rats and in FA+ EMR treated group, while significantly increased in FA treated group. Conclusion: According to our biochemical and histopathological findings, administration of FA reduced the renal injury effects of EMR.