Title of article
Ginger Extract Reduces Chronic Morphine-Induced Neuroinflammation and Glial Activation in Nucleus Accumbens of Rats
Author/Authors
Torkzadeh-Mahani, Shima Department of Biology - School of Sciences - Shahid Bahonar University of Kerman , Esmaeili-Mahani, Saeed Department of Biology - School of Sciences - Shahid Bahonar University of Kerman , Nasri, Sima Department of Biology - Payame Noor University , Darvishzadeh, Fatemeh Institute of Neuropharmacology - Kerman University of Medical Sciences , Naderi, Reyhaneh Department of Biology - School of Sciences - Shahid Bahonar University of Kerman
Pages
7
From page
66
To page
72
Abstract
Background: Chronic usage of morphine elicits the production of inflammatory factors by glial cells and
induces neuroinflammation. Ginger (Zingiber Officinale Roscoe) is a medicinal herb that has antiinflammatory properties. It has been reported that ginger shows anti-addictive effects against chronic usage
of morphine; however, its influence on morphine-induced neuroinflammation has not yet been clarified.
Methods: Morphine (12 mg/kg) was administrated intraperitoneally for 6 consecutive days. To evaluate the
effect of ginger on morphine-induced neuroinflammation, ginger extract (100 mg/kg) was given orally 30
minutes before morphine. Glial fibrillary acidic protein (GFAP) and P38 mitogen-activated protein kinase
(p38 MAPK) levels were assayed by immunoblotting in the rat nucleus accumbens (NAcc).
Findings: The injection of chronic morphine increased the levels of proteins involved in neuroinflammation
(p38 MAPK and GFAP) in NAcc. Furthermore, the levels of p38 MAPK and GFAP significantly returned to
the control levels by ginger extract.
Conclusion: The results suggest that the ginger extract can reduce morphine-induced neuroinflammation in NAcc.
Keywords
Morphine , Ginger , p38 Mitogen-Activated Protein Kinases , Glial fibrillary acidic protein , Nucleus accumbens Rats
Journal title
Addiction and Health
Serial Year
2019
Record number
2497648
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