Title of article :
Effect of Exercise Training on Tropomodulin-2 Gene Expression in Cerebellum of Diabetic Rats
Author/Authors :
Taherabadi, Jalal Department of Sport Sciences - Lorestan University, Khoram Abad, Iran , Rahmati, Masoud Department of Sport Sciences - Lorestan University, Khoram Abad, Iran , Mirnasuri, Rahim Department of Sport Sciences - Lorestan University, Khoram Abad, Iran , Kazemi, Abdolreza Department of Sport Sciences - Vali-E-Asr University of Rafsanjan, Kerman, Iran
Abstract :
Objective: It is well documented that exercise training (ET)
imposes beneficial effects on diabetes mellitus and its complication
such as diabetic peripheral neuropathy (DPN). Regarding the
importance of tropomodulin-2 (TMOD2) in nervous system
plasticity, this protein may be recognized as a candidate mechanism
for ET-induced neuroplasticity. The aim of this study was to
investigate the effects of ET on cerebellar gene expression of
TMOD2 in rats with DPN.
Materials and Methods: Animals were randomly divided into
three groups: healthy control (C), diabetic control (DC) and diabetic
trained (DT). Diabetes was induced by a single intraperitoneal
injection of streptozotocin. Behavioral nociception assessment was
carried out by Von Frey Filaments and tail-flick tests. TMOD2 gene
expression was assessed by real time-PCR.
Results: The mRNA levels of TMOD2 increased to 0.50-fold (Pvalue:
0.005) in comparison of the sedentary controls after 6 weeks
of DPN. Also, TMOD2 gene expression in DT group was decreased
to -0.68-fold changes in comparison of the C group (P-value: 0.001).
In addition, the TMOD2 gene expression in DT group was lower
than the DC group (P-value: 0.0001).
Conclusion: The TMOD2 mRNA level in rat’s cerebellum was
affected by ET and DPN, but its exact physiological roles were not
clarified. Hence, identifying the importance of TMOD2 in DPN
needs further research.
Keywords :
Plasticity , Tropomodulin 2 , Exercise training , Diabetic peripheral neuropathy
Journal title :
Iranian Journal of Diabetes and Obesity
