Title of article :
Antibacterial Resistance Pattern of Acinetobacter baumannii in Burn Patients in Northeast of Iran
Author/Authors :
sedaghat, alireza Lung Disease Research Center - Faculty of Medicine - Mashhad University of Medicine Sciences , khadem-rezaiyan, majid Department of Community Medicine and Public Health - Faculty of Medicine - Mashhad University of Medical Sciences , ahmadabadi, ali Surgical Oncology Research Center - Mashhad University of Medical Sciences , abbaspour, hassan Faculty of Medicine - Mashhad University of Medical Sciences , youssefi, masoud Department of Microbiology and Virology - School of Medicine - Mashhad University of Medical Sciences , shirzad, mohammad moein Student Research Committee - Faculty of Medicine - Mashhad University of Medical Sciences , esfahani, mohammadhossein Student Research Committee - Faculty of Medicine - Mashhad University of Medical Sciences , mirzaei, mohammad Student Research Committee - Faculty of Medicine - Mashhad University of Medical Sciences , ramezani, mohammad Student Research Committee - Faculty of Medicine - Mashhad University of Medical Sciences
Abstract :
background: globally, acinetobacter spp., most commonly, acinetobacter baumannii, are one of the most common gram-negative nosocomial infections, especially in intensive care units (icus) and burn wards. because of the pathogens’ ability to survive for a long time, the eradication of the pathogen from these wards remains a great concern. simultaneously, the remarkable increase in antibacterial resistance among a. baumannii strains in recent years has raised a great deal of concern. objectives: the study assessed the prevalence and antibacterial resistance pattern of a. baumannii in the only academic-affiliated burn center in northeastern iran in 2012-2014. methods: in this cross-sectional study, 5,080 samples from patients admitted to two burnt wards and one burn icu were included. the samples were from different sources includingwoundtissue, blood, bronchial secretion, and urine. the antibacterial resistance pattern was determined using relevant antibiotics based on the clinical and laboratory standards institut (clsi) instructions. results: acinetobacter spp. were found in 39% of the acquired cultures (1,985 out of 5,080) and 51.9% of bacterial positive cultures (1985 out of 3823). the resistance rate of acinetobacter spp. against antibiotics varied from 0.9% for colistin to 100% for piperacillin-tazobactam. all acinetobacter spp. were multidrug-resistant (mdr) due to considerable resistance to fluoroquinolones (95%), cephalosporins (93% - 98%), penicillins (97%), carbapenems (94% - 95%), and beta-lactamase inhibitors (87% - 100%). conclusions: given that infections are amajorcause of mortality inburnwards, the high prevalence of mdrisolates of acinetobacter spp. in this burn center suggests that local antibiotic prescription policies should be revised and infection control strategies should beimproved. also, antibiotic cyclingandrestrict infection control strategies shouldbeimplementedin high-riskwardssuch asburn units.
Keywords :
Antimicrobial Drug Resistance , Acinetobacter baumannii , Burn Units
Journal title :
Jundishapur Journal of Microbiology (JJM)
