Title of article :
Gene and Biochemical Pathway Evaluation of Burns Injury via Protein-Protein Interaction Network Analysis
Author/Authors :
Rezaei-Tavirani, Majid Faculty of Medicine - Iran University of Medical Sciences , Mansouri, Vahid Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences , Rezaei Tavirani, Mostafa Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences , Rostami-Nejad, Mohammad Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences , Bashash, Davood Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences , Zamanian Azodi, Mona Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences
Abstract :
Background: Severe burns injury can affect several vital systems in the body and can cause
inflammation in organs such as the heart, liver, and kidney. Many inflammatory mediators and
regulatory hormones related to burn injuries are recognized. In this study, the genes related to
burn injury interacted via network analysis, and the central nodes were enriched through gene
ontology (GO). Materials and Methods: Disease query of STRING database was used for
data gathering, and the network was constructed using Cytoscape software version 3.6.0. After
gene screening, the central nodes were enriched via GO analysis by ClueGO. The highlighted
genes and pathways were clustered and analyzed in detail. Results: Among 1067 genes, 35
critical genes that are involved in the 14 highlighted biochemical pathways were recognized.
Interpretation of the finding indicates that a number of central genes can be considered as
potential biomarkers related to burn injury. Conclusion: Can we revise to “Burn injuries have
features that are common to several diseases and increases their risk.
Keywords :
Burn , Gene , Biomarker , Protein-Protein Interaction Network , Biochemical Pathway
Journal title :
Galen Medical Journal (GMJ)
