The Effect of Cupressus Sempervirens on Ulcerative Colitis: Do Pathological Changes Improve by Oxidative Stress Amelioration?

An important paradigm in the biochemical basis of diseases and pharmacological approach during recent decades has been focused on oxidative stress modulation in many inflammatory diseases. Ulcerative colitis (UC) has attracted great attention for the past few years because of the wait for better therapeutic modalities. As many other inflammatory diseases, this disease is also believed to be partially the result of extensive oxidative stress [1]. There are many review articles and many more original articles that have emphasized on oxidative stress as an important factor for the pathogenesis of ulcerative colitis [2-4]. Therefore, researchers have tried many anti-oxidative therapies to treat UC not only in animal models but also in human disease [5, 6]. Unexpectedly, the decrease in important factors pertinent to oxidative stress have not been constantly related to restoration of colon structure in accordance with pathological studies [7]. In human disease, there have been some exceptions to provide accurate evidences suggesting that oxidative stress is a pivotal prospect in the modulation of the destruction of colon tissue.