Title of article :
Delayed-Onset Transient Light Sensitivity Syndrome after Corneal Collagen Cross-Linking: A Case Series
Author/Authors :
Moshirfar, Majid John A. Moran Eye Center - Department of Ophthalmology and Visual Sciences - University of Utah School of Medicine - Salt Lake City, USA , Vaidyanathan, Uma McGovern Medical School at the University of Texas Health Science Center at Houston, USA , Hopping, Grant C McGovern Medical School at the University of Texas Health Science Center at Houston, USA , Ronquillo, Yasmyne C Hoopes Durrie Rivera Research Center - Hoopes Vision, USA , Hoopes, Phillip C Hoopes Durrie Rivera Research Center - Hoopes Vision, USA
Abstract :
In this case series, we report a potentially novel association of corneal collagen crosslinking (CCL) with the development of photophobia symptoms in a series of patients at a tertiary ophthalmology clinic and describe their clinical course. Photosensitivity is a rare and seemingly unpredictable complication of refractive surgery but can present as a disabling, bilateral ocular pain that requires immediate treatment. This complication, termed transient light-sensitivity syndrome (TLSS), can have a substantially delayed presentation after ocular procedures and is associated with inflammation of structures in the anterior chamber that can be imperceptible on slit-lamp examination. Traditionally, exposure to high-energy femtosecond lasers is hypothesized to create stromal gas bubbles powering postoperative inflammatory reactions. TLSS-like symptoms after CCL may be due to a secondary inflammatory response involving activated keratocytes and cytokine release. However, free radical damage from the interaction of riboflavin and ultraviolet in CCL may also drive this inflammatory process
Keywords :
Cornea , Collagen , Cross-Linking Reagents , Riboflavin , Photosensitivity Disorders , Photophobia
Journal title :
Medical Hypothesis, Discovery & Innovation Ophthalmology
