Title of article
Enhanced Th17 Responses in Patients with Autoimmune Hepatitis
Author/Authors
Behfarjam, Farinaz Clinical Genetics De-partment, National Institute of Genetic Engineering and Biotechnology theran , Nasseri-Moghaddam, Siavash Digestive Diseases Research Center - Digestive Diseases Research Institute - Tehran University of Medical Sciences , Jadali, Zohreh Department of Immunology - School of Public Health - Tehran Univer-sity of Medical Sciences
Pages
6
From page
98
To page
103
Abstract
T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH.
METHODS
A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR).
RESULTS
The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05).
CONCLUSION
Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH.
Keywords
Autoimmune hepatitis , Autoimmunity-Gene Expression Profiling , Cytokines
Journal title
Middle East Journal of Digestive Diseases(MEJDD)
Serial Year
2019
Record number
2500949
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