Title of article :
Effect of Exercise Training and Aging on Klotho Signaling in the Heart
Author/Authors :
Baghaiee, Behrouz Department of Physical Education and Sport Science - Jolfa Branch Islamic Azad University, Jolfa, Iran , Barzegari, Maliheh Deparment of Nutrition in the Community - Tabriz University of Medical Science, Tabriz, Iran , Sadeghi Zali, Mohammad Hossein Department of Microbiology - Faculty of Veterinary Medicine - Urmia Branch Islamic Azad University, Urmia, Iran , Hakimi, Mehdi Department of Physical Education and Sport Science - Marivan Branch Islamic Azad University, Marivan, Iran
Abstract :
Aging, if accompanied by a sedentary lifestyle, can result in different diseases including cardiovascular diseases. Klotho, a protein
found in the kidneys and other tissues of the body, is influenced by age and level of physical activity. In this paper, using 66 papers
published in PubMed and SID between 1997 and 2018, we examined the mechanism of action of Klotho on cardiac hypertrophy
under senescence conditions. Studies have shown that aging results in the development of oxidative stress as well as increased
MAPK and TRPC6. These factors push the heart towards pathological hypertrophy, where deficiency of Klotho accelerates this trend.
Nevertheless, exercise training causes enhanced Klotho levels. This protein is able to inhibit oxidative stress as an upstream factor
in the activity of MAPK and TRPC6.
Keywords :
Exercise Training , Klotho , Aging
Journal title :
Journal of Clinical Research in Paramedical Sciences
