Title of article :
Targeted Delivery of Therapeutic Agents by Smart Nanocarrier for Treatment of Parkinson’s Disease: A Novel Brain Targeting Approach
Author/Authors :
Moradi, Fatemeh Department of Anatomical Sciences - School of Medicine - Iran University of Medical Sciences, Tehran , Parsaie, Houman Department of Anatomical Sciences - School of Medicine - Iran University of Medical Sciences, Tehran , Charkhat Gorgich, Enam Alhagh Department of Anatomical Sciences - School of Medicine - Iran University of Medical Sciences, Tehran
Abstract :
Parkinson’s disease (PD) stays a standout amongst the
most well-known and partially treatable age-related neurodegenerative movement disorders. It is described by
irreversible demolition of dopamine-producing neurons
in the substantia nigra and formation of α-synucleincontaining Lewy bodies (1). The principal motor manifestations such as resting tremor, bradykinesia, rigidity and
postural imbalance occur based on the reduction in synthesis of dopamine (DA) in the striatum caused by the progressive degeneration of DAergic neurons, subsequently,
volumetric changes occur in different regions of the brain
of the patients (1, 2).
Keywords :
Parkinson’s Disease , Nanomedicine , Liposomes , Drug Delivery Systems , Targeted Therapy
Journal title :
Gene Cell Tissue
