Removal of Tumor Cells from Spermatogonial Cells by Application of Smart Nanoparticles

In recent years, despite successful treatment in more than 70% of testicular cancers in children (1) with radiotherapy and chemotherapy, 20% - 30% of them have azoospermia in the puberty or a significant reduction in sperm count (1, 2). This could endanger their quality of life (3). Currently, there are no methods for preserving the fertility of children with testicular cancer before puberty (4, 5) and the use of spermatogonial stem cells (SSCs) can be effective as an approach to sustain the fertility of these children (6).