Preconditioning Can Improve Osteogenic Potential of Mesenchymal Stem Cells in Hypothyroidism

Thyroid hormones (TH) have a critical role in bone growth and metabolism (1) through direct or indirect action of TH on osteoblast and osteoclast cells (2). In patients with hypothyroidism, there is a reduction in bone turnover and increased fracture risk (3). Moreover, bone marrow mesenchymal stem cells (BMSC) have receptors for thyroid hormones (TRα, TRβ) and so they are T3- responsive cells (4). It has been shown that the osteogenic differentiation of MSCs is influenced by T3 in a dosedependent manner. In this study, the 10 pM of T3 was the more effective dose on MSCs differentiation (5).