Letter to Editor: MicroRNA Polymorphism-Related T Helper Type 17/Regulatory T-Cell Imbalance May Lead to Idiopathic Recurrent Pregnancy Loss

We have read with great interest the recent article by Fazli and Ghorbian describing their study about the “Association study of non-coding RNA miR-499 and miR196a2 gene polymorphisms with the risk of idiopathic recurrent pregnancy loss” (1). We would like to thank the authors for sharing their valuable experiencewith non-coding RNA gene polymorphisms with the risk of idiopathic recurrent pregnancy loss (RPL). The authors found that the polymorphism of themiR-499 genehad a statistically significant association with the risk of RPL, unlike miR-196a2. They concluded that themiR-499 gene encoding regionmay be contributed as a genetic predisposition factor to RPL. However, the role of miR-499 and miR196a2 gene polymorphisms in patients with RPL remains unclear.