Title of article :
Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy
Author/Authors :
Rostami-Nejad, Mohammad Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Rezaei-Tavirani, Mostafa Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran , Zadeh-Esmaeel, Mohammad-Mehdi Skin Research Center - Shahid Beheshti University of Medical Sciences, Tehran , Rezaei Tavirani, Sina Proteomics Research Center - Shahid Beheshti University of Medical Sciences, Tehran , Akbari, Zahra Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences, Tehran , Esmaeili, Somayeh Traditional Medicine and Materia Medica Research Center - School of Traditional Medicine - Shahid Beheshti University of Medical Sciences, Tehran , Okhovatian, Farshad Physiotherapy Research Center - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Introduction: Laser therapy is known as an efficient approach in dermatology surgery. CO2 laser therapy is a gold standard treatment in skin surgery. This study aimed to evaluate the interferons change after CO2 laser surgery
Methods: Significant differentially-expressed genes (DEGs) of arm skin after 7 days of treatment by the CO2 laser relative to the controls are downloaded from Gene Expression Omnibus (GEO) and are included in the protein-protein interaction network via a STRING database (an application of Cytoscape software). The central DEGs were identified and enriched via gene ontology by using Clue GO software.
Results: A network including 78 DEGs and 100 neighbors was constructed and STAT1, MX1, ISG15, OAS1, IFIT1, IRF8, OASL, OAS2, and RSAD2 as hubs and STAT1, PTPRC, MX1, IRF8, ISG15, IL6, RORC, SAMSN1, and IFIT1 as bottlenecks were introduced. The cytokine-mediated signaling pathway, interferon gamma signaling, hepatitis C, interferon alpha/beta signaling, and the type I interferon signaling pathway were identified as 5 clusters of biological terms which are related to the central nodes.
Conclusion: It can be concluded that the cytokine-mediated signaling pathway is the major pathway that is dysregulated after laser application in the treated skin.
Keywords :
Laser CO2 , Skin , Interferon , Gene , Network
Journal title :
Journal of Lasers in Medical Sciences