Author/Authors :
Sessou, Philippe Research Unit on Communicable Diseases - Laboratory of Research in Applied Biology - Polytechnic School of Abomey-Calavi , Benin , Yovo, Mahudro Laboratory of Study and Research in Applied Biology - Polytechnic School of Abomey-Calavi - University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin , Towanou, Rodrigue Research Unit on Communicable Diseases - Laboratory of Research in Applied Biology - Polytechnic School of Abomey-Calavi , Benin , Ayihou,Yannick Research Unit on Communicable Diseases - Laboratory of Research in Applied Biology - Polytechnic School of Abomey-Calavi , Benin , Komagbe, Gwladys S. Research Unit on Communicable Diseases - Laboratory of Research in Applied Biology - Polytechnic School of Abomey-Calavi , Benin , Adinci, Justin Research Unit on Communicable Diseases - Laboratory of Research in Applied Biology - Polytechnic School of Abomey-Calavi , Benin , Ayaovi Yaovi, Bruno Research Unit on Communicable Diseases - Laboratory of Research in Applied Biology - Polytechnic School of Abomey-Calavi , Benin , Nestor Aguidissou, Oscar Research Unit on Communicable Diseases - Laboratory of Research in Applied Biology - Polytechnic School of Abomey-Calavi , Benin , Senou, Maximin Experimental and Clinical Biology Laboratory - National School of Applied Biosciences and Biotechnology - National University of Sciences, Technology, Engineering and Mathematics, P.O Box 14 Dassa-Zoume, Benin , Alain Alitonou, Guy Laboratory of Study and Research in Applied Biology - Polytechnic School of Abomey-Calavi - University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin , Avlessi, Félicien Laboratory of Study and Research in Applied Biology - Polytechnic School of Abomey-Calavi - University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin , Farougou, Souaïbou Research Unit on Communicable Diseases - Laboratory of Research in Applied Biology - Polytechnic School of Abomey-Calavi , Benin , Sohounhloue, Dominique Laboratory of Study and Research in Applied Biology - Polytechnic School of Abomey-Calavi - University of Abomey-Calavi, 01 P.O.Box 2009, Cotonou, Benin
Abstract :
Background and objectives: The present work aimed to evaluate the acute toxicity of Aeollanthus
pubescens essential oil, whose antimicrobial activity has been proven in vitro by previous studies and
to examine the effects of this essential oil on the biochemical parameters (transaminases ALT and
AST, urea, creatinine and cholesterol) and hematological and histological factors in Wistar rats
subjected to this volatile oil. Methods: Nine male Wistar rats, 12 weeks old weighing more than 140 g
were divided into three groups of three rats each; group one normal control rats; group two normal
rats which received the extract of A. pubescens by gavage at a dosage of 2000 mg/kg of body weight
and finally gropup three consisting of normal rats receiving the extract of A. pubescens by
intramuscular injection at a dosage of 2000mg/kg body weight. The duration of the experiment was 14
days. Results: At the end of the study, the essential oil of A. pubescens did not cause any mortality in
the experimental rats, which indicated that the extract did not exhibit acute toxicity at this dose.
Biochemical and hematological analyses revealed no adverse effects (p>0.05) on the hepatic, renal,
lipid and hematological parameters measured in these animals. Histological examination showed no
alteration of the hepatic and renal structures. Conclusion: This oil can be considered generally
recognized as safe at the experimental dosage and can be used in the fight against pathologies of
bacterial origin.
