Title of article :
Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice
Author/Authors :
Hakimizadeh, Elham Physiology - Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences, Iran , Jandaghi, Faezeh Student Research Committee - Rafsanjan University of Medical Sciences, Iran , Hajmohammadi, Mojdeh Physiology - Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences, Iran , Fatemi, Iman Research Center for Tropical and Infectious Diseases - Kerman University of Medical Sciences, Iran , Kaeidi, Ayat Physiology - Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences, Iran , Shamsizadeh, Ali Physiology - Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences, Iran , Allahtavakoli, Mohammad Physiology - Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences, Iran
Abstract :
Background and objectives: Menopause is associated with depression as well as emotional and
memory disorders. Based on the anti-inflammatory and antioxidant effects of pistachio, its effect on
depression, cognitive function, anxiety and physical power in ovariectomized mice was investigated.
Methods: In the current study, fifty female mice were used. They were aliquoted into five groups:
control, ovariectomy (OVX), ovariectomy + DMSO, ovariectomy +10 mg/kg pistachioextract and
Ovariectomy +100 mg/kg pistachio extract. In order to prepare the required extract, pistachio nuts
were powdered (100 g) and macerated in 1 L of ethanol (80%) for 72 h. Pistachio extract was used
orally once a day in ovariectomized mice for sixty days. Anxiety, depression, working memory and
physical power were evaluated by the Elevated plus-maze (EPM) test, Forced swimming test (FST), Y
maze and swimming exhaustion test, respectively. Results: The results showed that extract of
pistachio (more potentially at the dose of 100 mg/kg) decreased anxiety-like behaviors and depression;
besides, increase in working memory and physical power was observed in the ovariectomized mice.
Conclusion: The findings of the current investigation suggest that pistachio extract could be used as a
potential strategy for the attenuation of ovariectomy-related manifestation.
Keywords :
mice , Ovariectomy , Pistacia vera
Journal title :
Research Journal of Pharmacognosy