Author/Authors :
Azari, Iman Department of Medical Genetics - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ghafouri-Fard, Soudeh Department of Medical Genetics - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Omrani, Davood Urogenital Stem Cell Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Arsang-Jang, Shahram Clinical Research Development Center (CRDU) - Qom University of Medical Sciences, Iran , Kordi Tamandani, Mohammad Department of Biology - University of Sistan and Baluchistan, Zahedan, Iran , Saroone Rigi, Mehrnaz Shafa Surgery Center - Zahedan, Sistan and Baluchistan, Iran , Rafiee, Sara Department of Biology - University of Sistan and Baluchistan, Zahedan, Iran , Pouresmaeili, Farkhondeh Department of Medical Genetics - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Taheri, Mohammad Urogenital Stem Cell Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Background:Intrauterine growth restriction (IUGR), a pathologic diminution of the rate of fetal growth, has
been associated with alterations in expression of several genes. However, the role of long non-coding RNAs
(lncRNAs) in its pathogenesis has not been studied.
Methods: In this study we evaluated the expression of four lncRNAs namely, nuclear paraspeckle assembly
transcript (NEAT1), taurine up-regulated 1 (TUG1), p21-associated ncRNA DNA damage-activated (PANDA),
and metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) in placenta samples obtained from
IUGR and normal pregnancies to determine their possible contributions in the pathogenesis of IUGR.
Results:We found no significant differences in expression levels between cases and controls. We also found no
correlation between expression and clinical data of study participants; however, we found significant
correlations between expression levels of all the assessed lncRNAs in both cases and controls.
Conclusions: These results imply the existence of a possible shared regulatory mechanism for the expression
of these transcripts in placenta. Future studies are needed to perform such evaluations in larger sample sizes or
in animal models in earlier stages of pregnancy.
Keywords :
IUGR , NEAT1 , MALAT1 , PANDA , Placenta , TUG1