An efficient synthesis of amidodiester derivatives via a pseudo five-component one-pot reaction under solvent-free conditions

We reported a green, simple and efficient method for the synthesis of amidodiester derivatives employing a multicomponent and one-pot condensation reaction of between Meldrum’s acid, aryl aldehydes with alkyl isocyanide in the presence of two equivalents alcohols under solvent-free conditions at room temperature. This new protocol offers advantages such as pseudo five-component one-pot reaction, aerobic conditions, milder reaction conditions without additives, high yields, easy work-up and does not involve any hazardous solvent. Therefore, this procedure could be classified as green chemistry. To Meldrum’s acid at r.t. was added aryl aldehyde. The reaction mixture was stirred for 5 min. Then, alcohols was added at this temperature. Reaction mixture was then stirred for one minute, alkyl isocyanide was added and the reaction mixture was stirred for more 24h at room temperature. The progress of the reaction was monitored by TLC. After completion of the reaction, The viscose oil yellow was collected and to afford the pure title compounds. The structures of compounds were deduced from elemental analysis and their IR, 1H NMR, 13C NMR spectra.