Biosynthesis of Fe3O4-magnetic nanoparticles using Clover Leaf aqueous extract: Green synthesis of oxazole derivatives

1,3-oxazole derivatives were prepared via multicomponent reaction of α-bromo ketones, acid chlorides and ammonium thiocyanate in the presence of catalytic amount of Fe3O4 MNPs in water at 50oC in good yields. Also, the reaction of alkyl (aryl) isothiocyanates and -bromo ketones in the presence of catalytic amount of Fe3O4 MNPs in water at 50oC are investigated. The catalyst was reused five times with minor decrease in its catalytic activity. In addition, high yields, easy procedure, easy separation of catalyst from the mixture of reactions are the advantages of these reactions.