Author/Authors :
Zaibi, Haifa Faculty of Medicine of Tunis - University of Tunis El Manar, Tunisia, Charles Nicole Pulmonology Department, Tunis, Tunisia , Fessi, Rana Faculty of Medicine of Tunis - University of Tunis El Manar, Tunisia, Charles Nicole Pulmonology Department, Tunis, Tunisia , Dhahri, Besma Faculty of Medicine of Tunis - University of Tunis El Manar, Tunisia, Charles Nicole Pulmonology Department, Tunis, Tunisia , Ben Amar, Jihen Faculty of Medicine of Tunis - University of Tunis El Manar, Tunisia, Charles Nicole Pulmonology Department, Tunis, Tunisia , Aouina, Hichem Faculty of Medicine of Tunis - University of Tunis El Manar, Tunisia, Charles Nicole Pulmonology Department, Tunis, Tunisia
Abstract :
Tracheobronchopathia osteochondroplastica is a rare idiopathic disease of the
trachea and the main bronchi, characterized by multiple submucosal
osteocartilaginous nodules. Although the etiology of tracheobronchopathia
osteochondroplastica remains unknown, several theories have been proposed.
We report a case of a 47-year-old non-smoker woman with wheezing dyspnea
over the past two years, which was treated as asthma without improvement.
Investigations, including chest computed tomography scan, fiberoptic
bronchoscopy, and endobronchial biopsy, indicated tracheobronchial amyloid
light-chain (AL) amyloidosis. Thirteen years later, she was admitted for cough
and wheezing. The bronchoscopic examination demonstrated nodular lesions
distributed along the cartilaginous rings of the lower portion of the trachea and
the main bronchi. Endobronchial biopsy confirmed tracheobronchopathia
osteochondroplastica. We found tracheobronchopathia osteochondroplastica to
be the end stage of amyloidosis.
