Title of article :
The effect of cerium oxide nanoparticles on memory impairment and antioxidant capacity in streptozotocininduced diabetic rats
Author/Authors :
Gharebaghi, Alireza Hamadan University of Medical Sciences, Hamadan , Ranjbar, Akram Department of Pharmacy - School of Pharmacy - Hamadan University of Medical Sciences, Hamadan , Artimani, Tayebe Hamadan University of Medical Sciences, Hamadan , Mirzaeiseresht, Banafsheh Hamadan University of Medical Sciences, Hamadan , Soleimani Asl, Sara Hamadan University of Medical Sciences, Hamadan
Abstract :
Introduction: Diabetes mellitus is a major chronic metabolic disorder that induces
memory and learning impairment. Herein, we investigated the protective effects of
cerium oxide nanoparticles (CeO2) against streptozotocin (STZ)-induced memory
impairment and antioxidant capacity in the diabetic rats.
Methods: Adult male Wistar rats were assigned into the control, STZ, CeO2 and STZ
plus CeO2 groups. Diabetes was induced using STZ and next CeNPs (60mg/kg) was
administered for 14 constitutive days. The day after the last administration, spatial
memory was assessed using the Morris water maze (MWM). Ultimately, the level of
total antioxidant capacity (TAC) was investigated.
Results: Our results showed that STZ significantly decreased the spatial memory
and CeO2 could compensate for these changes. Furthermore, TAC increased
following administration of CeO2 in the diabetic rats.
Conclusion: The results of this study suggest that CeO2 seems to be able to
improve STZ-induced neurotoxicity in the rats.
Keywords :
Streptozotocin , Cerium oxide nanoparticles , Spatial memory , Antioxidant capacity
Journal title :
Physiology and Pharmacology
