The Effects of Omega-3 on Liver Damage after Acute Myocardial Infarction: A Randomized Controlled Clinical Trial

Background: Abnormal liver function test results are often observed in patients with acute Myocardial Infarction (MI). Objectives: This study aimed to evaluate the effects of omega-3 fatty acids on Alanine Aminotransferase (ALT) activity elevation after MI-induced liver injury. Methods: In this randomized clinical trial, 75 patients with acute MI were randomly allocated to an intervention and a control group. The intervention group received 1 gram per day equal to three capsules of Pikasol (fish oil) for three months, while the control group received the routine treatment after MI. In all samples, plasma concentrations of ALT were assessed on the admission day and 2, 30, 60, and 90 days after the intervention. The data were analyzed using the SPSS 16 software, and P < 0.05 was set as the level of statistical significance. Results: The results showed no significant differences between the two groups regarding age, sex, Body Mass Index (BMI), and systolic and diastolic blood pressure. The results also indicated no significant differences between the two groups concerning the serum level of ALT on the day of admission (P = 0.68), day 2 (P = 0.79), day 30 (P = 0.86), day 60 (P = 0.09), and day 90 (P = 0.64). Conclusion: The study results suggested that the patients receiving omega-3 supplementation following MI had similar ALT levels to those who received no supplementations. However, further studies with larger sample sizes are needed to confirm the results.