Author/Authors :
Khalili, Ali Lung Transplantation Research Center (LTRC) - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Fani, Kamal Cardiac Anesthesiology Department - Anesthesiology Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Naziri, Mahdyieh Department of Biostatistics - School of Public Health - Iran University of Medical Sciences, Tehran, Iran , Foroughi, Mahnoosh Cardiovascular Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Dastan, Farzaneh Clinical Pharmacy Department - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Dabbagh, Ali Cardiac Anesthesiology Department - Anesthesiology Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Jelveh Moghadam, Hosein Ali Cardiac Anesthesiology Department - Anesthesiology Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Jahangirifard, Alireza Chronic Respiratory Diseases Research Center (LTRC) - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Background: L-carnitine seems to be able to prevent complications after heart surgery using Cardiopulmonary bypass (CPB) and the adverse effects of pump usage. This study aimed to evaluates the effects of L-carnitine on cardiac biomarkers and operation characteristics after coronary artery bypass graft (CABG) surgery.Methods and materials: In this randomized triple-blinded, sixty patients undergoing elective CABG surgery were divided into three equal groups to receive 2gr oral L-carnitine (group A), 5gr oral L-carnitine (group B) and placebo (group C) 2 hours before surgery. IL-6, creatinine, and high sensitivity C-reactive protein (HS–CRP) levels, CK-MB, cardiac troponin and inotrope administration in ICU or after CPB were recorded for all patients at baseline levels and at 8 or 24 hours postoperatively.Results: There was an evidence of a significant difference in CPK-MB level and number of red blood cell packed used in group A was lower than group C (p<0.05). The cardiac troponin level 8 hours after surgery significantly decreased in two treatment groups in comparison to group C (p<0.05). The need for inotropic support after weaning from CPB, in B group was statistically higher than C group (p=0.021).Conclusion: Although L-carnitine adjunct therapy appears not to be associated with IL-6 and HS–CRP levels, it had beneficial effects on cardiac troponin and CPK-MB levels.
Keywords :
Coronary artery bypass graft surgery , IL-6 , L-carnitine , Troponin , HS–CRP levels
