Title of article
Hormone replacement therapy in Leber's hereditary optic neuropathy: Accelerated visual recovery in vivo
Author/Authors
Fantini Michele Doheny Eye Institute - Los Angeles - CA, USA , Asanad Samuel Doheny Eye Institute - Los Angeles - CA, USA , Karanjia Rustum Doheny Eye Institute - Los Angeles - CA, USA , Sadun Alfredo Doheny Eye Institute - Los Angeles - CA, USA
Pages
4
From page
102
To page
105
Abstract
To report an accelerated course of visual recovery in a case of Leber's hereditary optic neuropathy (LHON) following treatment with
idebenone and hormone replacement therapy (HRT). We hereby demonstrate the clinical utility of estrogen's protective role in LHON in vivo.
Methods: We present a case of LHON in a menopausal woman carrying the 10197 mitochondrial DNA (mtDNA) mutation, who experienced
loss of vision shortly after discontinuing her estrogen replacement regimen. Functional visual outcomes are reported following treatment with
idebenone and HRT.
Results: The patient exhibited an accelerated course of visual recovery, experiencing improvement in vision as early as one month and complete
reversal of vision loss by eight months post-therapy.
Conclusion: Idebenone treatment combined with HRT may have a synergistic effect in enhancing cellular bioenergetics and may explain the
patient's accelerated visual improvement
Keywords
Hormone replacement therapy , Accelerated visual improvement , Mitochondrial disease , Leber's hereditary optic neuropathy
Journal title
Journal of Current Ophthalmology
Serial Year
2019
Record number
2503151
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