Author/Authors :
Mbangiwa, Tshepiso Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana , Melamu, Pinkie Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana , Molebatsi, Kesaobaka Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana , Anderson, Motswedi Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana , Bhebhe, Lynnette Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana , Moyo, Sikhulile Moyo, Sikhulile Phinius, Bonolo Choga, Wonderful Blackard, Jason T Kasvosve, Ishmael Kammerer, Betsy Mayondi, Gloria Lockman, Shahin Gaseitsiwe, Simani , Phinius, Bonolo Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana , Choga, Wonderful Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana , Blackard, Jason T University of Cincinnati College of Medicine - Cincinnati - United States , Kasvosve, Ishmael 3University of Botswana - Gaborone - Botswana , Kammerer, Betsy Brigham and Women’s Hospital - Boston - United States , Mayondi, Gloria Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana , Lockman, Shahin Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana , Gaseitsiwe, Simani Botswana Harvard AIDS Institute Partnership - University of Botswana - Gaborone - Botswana
Abstract :
Background: Hepatitis B virus (HBV) infection during pregnancy is associated with an increased risk of premature birth, cesarean
sections, low birth weight, and an increased number of hospitalizations in infants. There are no reported data on the impact of
maternal HBV status on pregnancy and infant health outcomes in Botswana.
Objectives: We aimed to evaluate the association of maternal HBsAg+
/occult HBV infection at delivery with pregnancy and infant
health outcomes in Botswana.
Methods: HBsAg positivity was tested using a murex HBsAg ELISA kit while occult HBV (OBI) was tested using COBAS®
AmpliPrep
COBAS®
Taqman®
.
Results: The total number of maternal HBsAg+
and OBI infections was 57 out of 752 and termed as maternal HBV. Binary logistic
regression was used to explore the possible impact of maternal HBV status on each outcome, adjusted for maternal HIV status, ART
use during pregnancy, and maternal age.
Conclusions: In conclusion, there was no association between maternal HBsAg+
/occult HBV infection and preterm birth (< 37
weeks), stillbirth, low birth weight (< 2.5 kg), and infant hospitalization (by 24 months).
Keywords :
Pregnant Women , Hepatitis B Virus , Pregnancy Outcomes , Botswana
