Antibacterial Effects of Agicoat Silver Crystalline Nanofibers on Wound Infection Agents

Background: Drug resistance is a major concern in the treatment of burn wounds. The present study aimed to evaluate the effects of silver crystalline nanofibers on the bacteria isolated from burn wounds at Imam Musa Kazim Hospital in Isfahan, Iran and compare the findings with the samples collected from the skin of healthy adults with standard collection bacteria. Methods: Agicoat nanosilver dressing was used as the antibacterial agent. The antibacterial effects of the silver nanoparticle solution and silver crystalline nanofibers were assessed using the well diffusion method. In addition, the macrodilution method was applied to determine the MIC and MBC of the silver crystalline nanofibers. Results: No significant difference was observed in the growth inhibition zone of the silver nanoparticle solution and crystalline nanofibers. Comparison of the effects of silver crystalline nanofibers on wound infection bacteria and healthy skin bacteria (MBC=0.128 mg/ml) were similar although the effects were more significant than the effects of tetracycline. Moreover, the standard bacterial strains were more sensitive to the nanofibers (MBC= 0.032). The antibacterial properties of the silver crystalline nanofibers reduced after the washing process (10 times; P < 0.001). Conclusion: According to the results, the silver crystalline nanofibers had significant antibacterial properties on burn wound infection bacteria.