Dexmedetomidine as an Additive to Local Anesthesia for Decreasing Intraocular Pressure in Glaucoma Surgery: A Randomized Trial

Background: Nowadays, the peribulbar block is used as a tool in glaucoma surgery. As a side effect, it increases intraocular pressure that raises the need for adjuvant medication to overcome this problem in the diseased eye. Dexmedetomidine has proven to decrease intraocular pressure (IOP) in the non-glaucomatous eye. Objectives: In a triple-blinded randomized study, dexmedetomidine as an adjuvant to the peribulbar block was used to decrease IOP in the diseased eye. Methods: We randomized 98 eyes to three groups, including D50 (35 eyes) with dexmedetomidine 50 g, D25 (33 eyes) with dexmedetomidine 25 g, or control group (C) (30 eyes) with the plain peribulbar block. The study was randomized triple-blinded, aiming at testing the effect of dexmedetomidine on IOP after block injection. Results: The pre-injection IOP was 27.71 2.52, 27.25 3.53, and 26.2 3.57 mmHg in groups D50, D25, and C, respectively, then increased to 29.711.69, 30.252.36 and 29.43.756 in groups D50, D25 and C, respectively, with P >0.05. The pressure decreased after the surgery to 10.861.478 in group D50, 10.751.63 in group D25, and 10.61.589 in group C, with no statistical differences (P > 0.05) between the groups. Conclusions: Dexmedetomidine did not decrease IOP in the glaucomatous eye.