The Effect of Two Types of Training Programs on the Expression of TrkB, Bax and Bcl-2 Genes in Male Rats After Induction of Cerebral Ischemia

Background: Physical activity and dynamic lifestyle play an important role in the prevention and treatment of some common neurological diseases. Onevaluable approach to increasing healthandreducing braindamageis to performanexerciseandphysical activity. Objectives: The aim of the present study was to investigate the effect of exercise pre-training on the intervening factors and complications of cerebral ischemia. Methods: In this study, forty Wistar rats were randomly divided into four groups, including (1) endurance training, (2) endurancecognitive training, (3) ischemia, and (4) control. The training was performed for 3 weeks. After the last training session, the rats had to undergo cerebral ischemia. The ischemia was induced by occlusion of both common carotid arteries for 30 min. Real-time PCR method was used to measure the expression level of TrkB, Bax, and Bcl-2 genes. Results: The levels of TrkB gene expression were significantly increased in the endurance training and endurance-cognitive training groups compared to the ischemia and control groups (P 0.05). There was a significant increase in the levels of Bcl-2 gene expression in the endurance training group compared to the ischemia group as well as the endurance-cognitive group compared to the ischemia and control groups (P 0.05). Also, the levels of Bax gene expression in the endurance training and endurance-cognitive groups were significantly lower than the control group (P 0.05). Conclusions: This study showed that exercise as a preconditioning stimulus has neuroprotective effects against cerebral ischemia.