Title of article :
The miR-223: An Inflammatory MicroRNA Involved in Pathogenesis of Multiple Sclerosis
Author/Authors :
Gharibi ، Saba Department of Genetics, Genetic Engineering and Genome Editing Laboratory - Faculty of Medicine, Yazd Reproductive Sciences Institute, Stem Cell Biology Research Center - Shahid Sadoughi University of Medical Sciences, International Campus , Moghimi ، Bahram Department of Genetics - Faculty of Medicine - Shahid Sadoughi University of Medical Sciences , Tahoori ، Mohammad Taher Department of immunology - Faculty of Medicine - Shahid Sadoughi University of Medical Sciences , Mahmoudi ، Mohammad Bagher Department of Genetic Research - ROJE Technologies , Shahvazian ، Ensieh Department of Genetic Research - ROJE Technologies , Farashahi Yazd ، Ehsan Genetic Engineering and Genome Editing Laboratory - Yazd Reproductive Sciences Institute, Stem Cell Biology Research Center - Shahid Sadoughi University of Medical Sciences
Abstract :
Multiple sclerosis (MS) is the most common autoimmune inflammatory demyelinating disease that affects the brain and spinal cord. Dysregulation or mutation of miRNA genes have been linked to the pathogenesis of MS. The miRNAs are short, 20-22 nucleotide long, single-stranded regulatory and nonprotein coding RNAs that modulate the expression of multiple target genes. Among miRNAs, miR-223 has been reported to play a critical role in MS. This review concentrates on the emerging role of miR-223 in inflammatory responses and specifically discusses how alterations in miR-223 expression are associated with the development of MS. This review also suggests that miR-223 can be used as a biomarker for diagnosis of MS and discovering novel therapeutics for MS treatment.
Keywords :
Inflammation , Marker , MicroRNA , miR , 223 , Multiple sclerosis
Journal title :
International Journal of Medical Laboratory
Journal title :
International Journal of Medical Laboratory
