Title of article :
Malathion-increased Hepatotoxicity in Diabetic Rats
Author/Authors :
Hosseini ، Azam Pharmaceutics Research Center, Institute of Neuropharmacology - Kerman University of Medical Sciences , Ahmadipour ، Ahmad Pharmaceutics Research Center, Institute of Neuropharmacology - Kerman University of Medical Sciences , Soltani ، Motahareh Pharmaceutics Research Center, Institute of Neuropharmacology - Kerman University of Medical Sciences , Mehdipour ، Mohammad Pharmaceutics Research Center, Institute of Neuropharmacology - Kerman University of Medical Sciences , Mandegary ، Ali Department of Pharmacology Toxicology - Pharmaceutics Research Center, Institute of Neuropharmacology, School of Pharmacy - Kerman University of Medical Sciences , Karami-Mohajeri ، Somayyeh Department of Pharmacology Toxicology - Pharmaceutics Research Center, Institute of Neuropharmacology, School of Pharmacy - Kerman University of Medical Sciences
Abstract :
Background: Malathion (MT), an organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of diabetes mellitus. Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats. Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg/day orally. After 28 days, fasting blood glucose, Glucose Tolerance Test (GTT), serum aminotransferases, and liver histopathology and antioxidant status were examined. Results: MT impaired GTT, caused alteration in histopathology of histopathology and antioxidant status of liver in non-diabetic rats. Impairment in GTT did not observe in diabetic rats exposed to MT, but histopathology changes and antioxidant status alteration was more severe. Conclusion: Repeated sub-lethal dose of MT exacerbated hepatotoxicity in diabetes condition through further impairment in the antioxidant defense system.
Keywords :
Organophosphorus , Diabetes , Liver , Oxidative stress
Journal title :
Pharmaceutical and Biomedical Research
Journal title :
Pharmaceutical and Biomedical Research
